Hsp105 Recombinant Rabbit Monoclonal Antibody [SD85-06] (ET1612-88)

UNIPROT #

Q92598

PROTEIN NAME

Hsp105

SYNONYMS

Antigen NY CO 25 antibody;Antigen NY-CO-25 antibody;DKFZp686M05240 antibody;Heat shock 105kD alpha antibody;Heat shock 105kD antibody;Heat shock 105kD beta antibody;Heat shock 105kDa protein 1 antibody;Heat shock 105kDa protein antibody;Heat shock 105kDa/110kDa protein 1 antibody;Heat shock 110 kDa protein antibody;Heat shock 110kDa protein antibody;Heat shock protein 105 kDa antibody;HS105_HUMAN antibody;HSP105 antibody;HSP105A antibody;HSP105B antibody;HSP110 antibody;HSPH 1 antibody;Hsph1 antibody;KIAA0201 antibody;NY CO 25 antibody

SEQUENCE SIMILARITIES

Belongs to the heat shock protein 70 family.

TISSUE SPECIFICITY

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent poly-peptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the low molecular weight HSPs, the immunophilins and the HSP 110 family. The HSP 110 family (also known as the HSP 105 family) is composed of HSP 105, Apg-1 and Apg-2. HSP 105 is a testis-specific and HSP 90-related protein. Research indicates that HSP 105 is specifically localized in the germ cells and may translocate into the nucleus after heat shock. It is suggested that HSP 105 may contribute to the stabilization of p53 proteins in the cytoplasm of the germ cells, preventing the potential induction of apoptosis by p53.