HOXA9 Rabbit Polyclonal Antibody (HA500077)

UNIPROT #

P31269

PROTEIN NAME

HOXA9

SYNONYMS

ABD-B antibody;Abd-B, drosophila, homolog of antibody;D6a9 antibody;Homeobox 1G antibody;Homeobox A9 antibody;Homeobox protein Hox-1.7 antibody;Homeobox protein Hox-1G antibody;Homeobox protein Hox-A9 antibody;Homeodomain protein HOXA9 antibody;Hox-1.7 antibody;Hox-1.7, mouse, homolog of antibody;HOX1 antibody;Hox1.7 antibody;Hox1G antibody;Hox1r5 antibody;Hoxa-9 antibody;Hoxa7 antibody;HOXA9 antibody;HOXA9/MSI2 fusion gene, included antibody;HOXA9/NUP98 fusion gene, included antibody;HXA9_HUMAN antibody;MGC1934 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

HOXA9, also known HOX1G, which belongs to the Abd-B homeobox family and transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells. HOXA9 is methylated on Arg-140 by PRMT5and methylation is critical for E-selectin induction. HOXA9 as a sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. HOXA9 is required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. HOXA9 is 30 kDa, but methylation of HOXA9 is about 35-40 kDa.