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Hormone sensitive lipase / HSL Recombinant Rabbit Monoclonal Antibody (IRS157RB)

Price: Regular price $278.00

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Catalog# IRS157RB

Rabbit Monoclonal to Hormone sensitive lipase / HSL

Tested for

  • mIHC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Hormone sensitive lipase / HSL Recombinant Rabbit Monoclonal Antibody (IRS157RB)

Immunogen

Synthetic peptide within human hsl aa 931-980.

Host

Rabbit

Positive Control

Human breast tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 117 kDa

Isotype

IgG

TARGET

UNIPROT #

Q05469

PROTEIN NAME

Hormone sensitive lipase / HSL

SYNONYMS

Hormone sensitive lipase antibody;Hormone sensitive lipase testicular isoform antibody;Hormone-sensitive lipase antibody;HSL antibody;LHS antibody;Lipase hormone sensitive antibody;LIPE antibody;LIPS_HUMAN antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane, caveola, Cytoplasm, cytosol, Lipid droplet.

FUNCTION

The main function of hormone-sensitive lipase is to mobilize stored fats. HSL functions to hydrolyze either a fatty acid from a triacylglycerol molecule, freeing a fatty acid and diglyceride, or a fatty acid from a diacylglycerol molecule, freeing a fatty acid and monoglyceride. This process allows energy metabolism in mammals. Although HSL is able to catalyze hydrolysis of triglycerides and diglycerides, another enzyme found in adipose tissue, adipose triglyceride lipase (ATGL), has a higher affinity for triglycerides than HSL, and ATGL predominantly acts as the enzyme for triglyceride-specific hydrolysis in the adipocyte. Hormone-sensitive lipase, which has 11-fold greater affinity for diglycerides than triglycerides, predominantly cleaves these diglycerides, forming 2-monoglyceride and a free fatty acid.

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