HOPX / HOD Recombinant Antibody [PSH10-32] - Rat IgG1 (Chimeric) (HA601484)

UNIPROT #

Q8R1H0

PROTEIN NAME

HOPX / HOD

SYNONYMS

CAMEO antibody;heart odd homeobox 1 protein antibody;HOD antibody;Homeodomain-only protein antibody;HOP antibody;HOP homeobox antibody;HOP_HUMAN antibody;HOPX antibody;LAGY antibody;Lung cancer-associated Y protein antibody;NECC1 antibody;Not expressed in choriocarcinoma clone 1 antibody;Not expressed in choriocarcinoma protein 1 antibody;OB1 antibody;odd homeobox 1 protein antibody;Odd homeobox protein 1 antibody;OTTHUMP00000158970 antibody;SMAP31 antibody;TOTO antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. It is an important regulator of cardiac development and a marker of hippocampal neural stem cells. The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.