Homer1 Recombinant Antibody [JE65-19] - Guinea pig IgG2 (Chimeric) (HA601465)

UNIPROT #

Q9Z2Y3

PROTEIN NAME

Homer1

SYNONYMS

HOME1_HUMAN antibody;Homer antibody;HOMER 1A antibody;HOMER 1B antibody;HOMER 1C antibody;Homer homolog 1 (Drosophila) antibody;homer homolog 1 antibody;Homer protein homolog 1 antibody;homer scaffolding protein 1 antibody;Homer, Drosophila, homolog of, 1 antibody;Homer, neuronal immediate early gene, 1 antibody;Homer-1 antibody;Homer1 antibody;HOMER1A antibody;HOMER1B antibody;HOMER1C antibody;SYN47 antibody;Ves 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, postsynaptic density, synapse, dendritic spine.

FUNCTION

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.