Homeobox protein cut-like 1 Recombinant Rabbit Monoclonal Antibody [PSH14-70] (HA723668)

UNIPROT #

P53564

PROTEIN NAME

Homeobox protein cut-like 1

SYNONYMS

CCAAT displacement protein antibody;CDP antibody;CDP/Cut antibody;CDP1 antibody;Clox antibody;COY1 antibody;Cut homeobox antibody;Cut homolog antibody;Cut like 1 antibody;Cut like homeobox 1 antibody;CUTL1 antibody;CUX antibody;Cux/CDP antibody;CUX1 antibody;Golgi integral membrane protein 6 antibody;GOLIM6 antibody;Homeobox protein cux 1 antibody;Nbla10317 antibody;p100 antibody;p110 antibody;p200 antibody;p75 antibody;Putative protein product of Nbla10317 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis (Probable). In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.