hnRNP Q Recombinant Rabbit Monoclonal Antibody [JG35-72] (ET7108-17)

UNIPROT #

O60506

PROTEIN NAME

hnRNP Q

SYNONYMS

cytoplasmic RNA-interacting protein antibody;dJ3J17.2 antibody;Glycine and tyrosine rich RNA binding protein antibody;Glycine- and tyrosine-rich RNA-binding protein antibody;GRY RBP antibody;GRY-RBP antibody;GRYRBP antibody;Heterogeneous nuclear ribonucleoprotein Q antibody;hnRNP Q antibody;HNRPQ antibody;HNRPQ_HUMAN antibody;HNRPQ1 antibody;NS1 associated protein 1 antibody;NS1-associated protein 1 antibody;NSAP1 antibody;pp68 antibody;RP1 3J17.2 antibody;Synaptotagmin binding cytoplasmic RNA interacting protein antibody;Synaptotagmin-binding antibody;Syncrip antibody

TISSUE SPECIFICITY

Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity).

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome.

FUNCTION

Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.