HMGA2 Recombinant Rabbit Monoclonal Antibody [PSH05-53] (HA722295)

UNIPROT #

P52926

PROTEIN NAME

HMGA2

SYNONYMS

HMGA 2 antibody;BABL antibody;High mobility group (nonhistone chromosomal) protein isoform I C antibody;High mobility group (nonhistone chromosomal) protein isoform IC antibody;High Mobility Group AT hook 2 antibody;High Mobility Group AT hook protein 2 antibody;High mobility group AT-hook protein 2 antibody;High mobility group protein HMGI C antibody;High mobility group protein HMGI-C antibody;High mobility group protein HMGIC antibody;High mobility group protein I, isoform C antibody;HMGA2 antibody;HMGA2_HUMAN antibody;HMGI C antibody;HMGIC antibody;LIPO antibody;Non histone chromosomal architectural protein HMGI C antibody;Non histone chromosomal architectural protein HMGIC antibody;Pygmy antibody;STQTL9 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene. This gene encodes a protein that belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhanceosome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with lipomas suggests a role in adipogenesis and mesenchymal differentiation. A gene knock-out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The expression of HMGA2 in adult tissues is commonly associated with both malignant and benign tumor formation, as well as certain characteristic cancer-promoting mutations. Homologous proteins with highly conserved sequences are found in other mammalian species, including lab mice (Mus musculus).