HLA F Recombinant Rabbit Monoclonal Antibody [JE54-04] (ET7110-39)

UNIPROT #

P30511

PROTEIN NAME

HLA F

SYNONYMS

CDA12 antibody;HLA 5.4 antibody;HLA class I histocompatibility antigen, alpha chain F antibody;HLA class I molecule antibody;HLA F antigen antibody;HLA-CDA12 antibody;HLA-F antibody;HLAF antibody;HLAF_HUMAN antibody;Leukocyte antigen F antibody;MHC class I antigen F antibody

SEQUENCE SIMILARITIES

Belongs to the MHC class I family.

TISSUE SPECIFICITY

Expressed in resting B cells (at protein level). Expressed in secondary lymphoid organs rich in B and T cells such as the tonsils, spleen, and thymus (at protein level). Expressed in the endothelial cells of the tonsils. Expressed on activated lymphoid cells including B cells, NK cells, CD4+ T cells and memory T cells (at protein level). Expressed in motor neurons of spinal cord.

DEVELOPMENTAL STAGE

Expressed in fetal liver (at protein level). Expressed in placenta villous mesenchyme, cytotrophoblast, syncytiotrophoblast and invasive extravillous trophoblast (at protein level).

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Lysosome membrane, early endosome membrane, cell membrane.

FUNCTION

Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors. Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production. Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions. May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity.