HLA-DRB4 Recombinant Rabbit Monoclonal Antibody [JE55-85] (ET7111-17)

UNIPROT #

P13762

PROTEIN NAME

HLA-DRB4

SYNONYMS

DR 4 antibody;DR beta 4 chain antibody;DR4 antibody;DRB1 transplantation antigen antibody;DRB4 antibody;DRB4_HUMAN antibody;HLA class II histocompatibility antigen antibody;HLA class II histocompatibility antigen DR beta 4 chain antibody;HLA-DRB4 antibody;Human leucocyte antigen DRB4 antibody;Leukocyte antigen antibody;Major histocompatibility complex class II DR beta 4 antibody;MHC class II antigen DRB4 antibody;MHC class II antigen HLA DR beta antibody;MHC class2 antigen antibody;MHC HLA DR-beta chain antibody

SUBCELLULAR LOCATION

Lysosome membrane, Endosome membrane, Late endosome membrane, trans-Golgi network membrane, Endoplasmic reticulum membrane, Cell membrane.

FUNCTION

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II α/β dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.