HLA-DR Rabbit Polyclonal Antibody (R1510-35)

UNIPROT #

P01903

PROTEIN NAME

HLA-DR

SYNONYMS

DASS-397D15.1 antibody;DR alpha chain antibody;DR alpha chain precursor antibody;DRA_HUMAN antibody;DRB1 antibody;DRB4 antibody;FLJ51114 antibody;Histocompatibility antigen HLA DR alpha antibody;Histocompatibility antigen HLA-DR alpha antibody;HLA class II histocompatibility antigen antibody;HLA class II histocompatibility antigen DR alpha chain antibody;HLA DR1B antibody;HLA DR3B antibody;HLA DRA antibody;HLA DRA1 antibody;HLA DRB1 antibody;HLA DRB3 antibody;HLA DRB4 antibody;HLA DRB5 antibody;HLA-DR histocompatibility type antibody;HLA-DRA antibody;HLADR4B antibody;HLADRA1 antibody;HLADRB antibody;Major histocompatibility complex class II DR alpha antibody;Major histocompatibility complex class II DR beta 1 antibody;Major histocompatibility complex class II DR beta 3 antibody;Major histocompatibility complex class II DR beta 4 antibody;Major histocompatibility complex class II DR beta 5 antibody;MGC117330 antibody;MHC cell surface glycoprotein antibody;MHC class II antigen DRA antibody;MHC II antibody;MLRW antibody;OTTHUMP00000029406 antibody;OTTHUMP00000029407 antibody

SEQUENCE SIMILARITIES

Belongs to the MHC class II family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.

SUBCELLULAR LOCATION

Lysosome membrane, Endosome membrane, Late endosome membrane, trans-Golgi network membrane, Endoplasmic reticulum membrane, Cell membrane.

FUNCTION

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.