HLA-DQA1 Recombinant Rabbit Monoclonal Antibody (IRS035)

UNIPROT #

P01909

PROTEIN NAME

HLA-DQA1

SYNONYMS

CD antibody;CELIAC1 antibody;DC 1 alpha chain antibody;DC alpha antibody;DC-1 alpha chain antibody;DC-alpha antibody;DC1, included antibody;DQ alpha 1 chain antibody;DQ-A1 antibody;DQ-DRW9 alpha chain antibody;DQA1_HUMAN antibody;FLJ27088 antibody;FLJ27328 antibody;Gluten-sensitive enteropathy (celiac disease) antibody;GSE antibody;HLA class II histocompatibility antigen antibody;HLA class II histocompatibility antigen, DQ alpha 1 chain antibody;HLA class II histocompatibility antigen, DQ(W3) alpha chain antibody;HLA-DCA antibody;HLA-DQA antibody;HLA-DQA1 antibody;HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 antibody;HLADC histocompatibility type antibody;Immune response antigens HIa, included antibody;leucocyte antigen DQA1 antibody;leukocyte antigen alpha chain antibody;LOC100133678 antibody;LOC100507686 antibody;LOC100509457 antibody;Major histocompatibility complex, class II, DQ alpha 1 antibody;MGC149527 antibody;MHC class II antigen antibody;MHC class II DQA1 antibody;MHC class II HLA-D alpha glycoprotein antibody;MHC class II HLA-DQ alpha 1 antibody;MHC class II surface glycoprotein antibody;MHC HLA-DQ alpha antibody;OTTHUMP00000029141 antibody;OTTHUMP00000176885 antibody;OTTHUMP00000178551 antibody;OTTHUMP00000178552 antibody;OTTHUMP00000233817 antibody

SEQUENCE SIMILARITIES

Belongs to the MHC class II family.

SUBCELLULAR LOCATION

Cell membrane. Endoplasmic reticulum membrane.

FUNCTION

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.HLA-DQA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells.