HLA Class 1 ABC Mouse Monoclonal Antibody [11C3] (EM1801-09)

UNIPROT #

P04439

PROTEIN NAME

HLA Class 1 ABC

SYNONYMS

Antigen presenting molecule antibody;HLA class I histocompatibility antigen, A 1 alpha chain antibody;HLAA antibody;Leukocyte antigen class I A antibody;Major histocompatibility complex, class I, A antibody;MHC class I antigen HLA A heavy chain antibody;AS antibody;HLA B protein antibody;HLA class I histocompatibility antigen, B alpha chain antibody;HLA-B antibody;HLA-B histocompatibility type antibody;HLAB antibody;leukocyte antigen class I-B antibody;lymphocyte antigen antibody;major histocompatibility complex, class I, B antibody;MHC class I antigen GN00104 antibody;MHC class I antigen HLA-B heavy chain antibody;MHC class I antigen SHCHA antibody;MHC Class I HLA heavy chain antibody;MHC HLA-B cell surface glycoprotein antibody;MHC HLA-B transmembrane glycoprotein antibody;SPDA1 antibody;1C07_HUMAN antibody;Cw-7 alpha chain antibody;D6S204 antibody;HLA class I histocompatibility antigen antibody;HLA class I histocompatibility antigen, C alpha chain antibody;HLA class I histocompatibility antigen, Cw-1 alpha chain antibody;HLA JY3 antibody;HLA-C antibody;HLA-C histocompatibility type antibody;HLA-Cw antibody;HLA-JY3 antibody;HLAC antibody;HLC C antibody;HLC-C antibody;human leukocyte antigen-C alpha chain antibody;major histocompatibility antigen HLA-C antibody;major histocompatibility complex, class I, C antibody;MHC class I antigen antibody;MHC class I antigen Cw 1 antibody;MHC class I antigen Cw*7 antibody;MHC class I antigen heavy chain HLA-C antibody;PSORS1 antibody

SUBCELLULAR LOCATION

Cell Membrane, Endoplasmic reticulum membrane.

FUNCTION

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.