Rabbit polyclonal primary
HKDC1 Rabbit Polyclonal Antibody (ER1803-32)
Recombinant protein within human hkdc1 aa 266-462 / 917.
LOVO, MCF-7, SiHa, rat kidney tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
BC016235 antibody; Hexokinase domain containing 1 antibody; Hexokinase domain-containing protein 1 antibody; Hkdc1 antibody; HKDC1_HUMAN antibody; Putative hexokinase HKDC1 antibody
Belongs to the hexokinase family.
Widely expressed. Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein level). Present at moderate level in the thyroid follicular epithelium (at protein level).
As the recently identified fifth isoform of hexokinase, HKDC1 catalyzes the rate-limiting and first obligatory step of glucose metabolism, which is the ATP-dependent phosphorylation of glucose to G6P. Though its particular biological function remains unclear, HKDC1 has been suggested to play a more major role in glucose metabolism during pregnancy, as the mother would need to provide enough energy for both herself and the fetus. HKDC1 is ubiquitously expressed, with the highest levels of expression in pharynx, thymus, colon, esophagus, and eye tissue.