Recombinant Rabbit monoclonal primary
HIF-1 beta Recombinant Rabbit Monoclonal Antibody [ST05-25] (ET1609-67)
Human liver tissue lysates, human liver tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
arnT antibody; ARNT protein antibody; ARNT_HUMAN antibody; Aryl hydrocarbon receptor nuclear translocator antibody; bHLHe2 antibody; Class E basic helix-loop-helix protein 2 antibody; Dioxin receptor antibody; Dioxin receptor nuclear translocator antibody; Drnt antibody; HIF 1 beta antibody; HIF 1beta antibody; HIF-1-beta antibody; HIF1-beta antibody; HIF1B antibody; HIF1beta antibody; Hypoxia Inducible Factor 1 antibody; Hypoxia inducible factor 1 beta antibody; Hypoxia-inducible factor 1-beta antibody; nuclear translocator antibody; Tango antibody
AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common “PAS” motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. Arnt 2 (aryl hydrocarbon receptor nuclear translocator 2), also known as Hif-2b or bHLHe1, is a 712 amino acid nuclear protein that is exclusively expressed in adult brain and kidney. Containing a basic helix-loop-helix (bHLH) domain, a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains, Arnt 2 specifically recognizes the xenobiotic response element (XRE).