HER2 / ErbB2 Rabbit Polyclonal Antibody (R1511-33)

UNIPROT #

P04626

PROTEIN NAME

HER2 / ErbB2

SYNONYMS

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody;C erb B2/neu protein antibody;CD340 antibody;CD340 antigen antibody;Cerb B2/neu protein antibody;CerbB2 antibody;Erb b2 receptor tyrosine kinase 2 antibody;ERBB2 antibody;ERBB2_HUMAN antibody;HER 2 antibody;HER 2/NEU antibody;HER2 antibody;Herstatin antibody;Human epidermal growth factor receptor 2 antibody;Metastatic lymph node gene 19 protein antibody;MLN 19 antibody;MLN19 antibody;NEU antibody;NEU proto oncogene antibody;Neuro/glioblastoma derived oncogene homolog antibody;Neuroblastoma/glioblastoma derived oncogene homolog antibody;NGL antibody;p185erbB2 antibody;Proto-oncogene c-ErbB-2 antibody;Proto-oncogene Neu antibody;Receptor tyrosine-protein kinase erbB-2 antibody;TKR1 antibody;Tyrosine kinase type cell surface receptor HER2 antibody;Tyrosine kinase-type cell surface receptor HER2 antibody;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody;V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody;V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody;V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody;Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

TISSUE SPECIFICITY

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues. Signaling via SEMA4C promotes phosphorylation at Tyr-1248. Dephosphorylated by PTPN12.

SUBCELLULAR LOCATION

Nucleus, Early endosome, Cell membrane, perinuclear region.

FUNCTION

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.