HEC1 Rabbit Polyclonal Antibody (ER1803-56)

UNIPROT #

O14777

PROTEIN NAME

HEC1

SYNONYMS

from Entrez Gene ; antibody;HEC antibody;Highly expressed in cancer antibody;Highly expressed in cancer protein antibody;Highly expressed in cancer rich in leucine heptad repeats antibody;HsHec1 antibody;hsNDC80 antibody;Kinetochore associated 2 antibody;Kinetochore associated protein 2 antibody;Kinetochore protein Hec1 antibody;Kinetochore protein NDC80 homolog antibody;Kinetochore-associated protein 2 antibody;KNTC2 antibody;ndc80 antibody;NDC80 homolog kinetochore complex component antibody;NDC80 kinetochore complex component homolog antibody;NDC80, S. cerevisiae, homolog of antibody;NDC80_HUMAN antibody;Retinoblastoma associated protein HEC antibody;Retinoblastoma-associated protein HEC antibody;TID3 antibody

SEQUENCE SIMILARITIES

Belongs to the NDC80/HEC1 family.

DEVELOPMENTAL STAGE

Expression peaks in mitosis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene. Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. This protein complex has microtubule-binding domains. HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.