Haptoglobin Mouse Monoclonal Antibody [5-D3] (M1510-37)

UNIPROT #

P00738

PROTEIN NAME

Haptoglobin

SYNONYMS

Binding peptide antibody;BP antibody;Haptoglobin alpha chain antibody;Haptoglobin alpha(1S) beta antibody;Haptoglobin alpha(2FS) beta antibody;Haptoglobin beta chain antibody;Haptoglobin, alpha polypeptide antibody;Haptoglobin, beta polypeptide antibody;HP antibody;HP2 ALPHA2 antibody;HP2ALPHA2 antibody;HPA1S antibody;HPT antibody;HPT_HUMAN antibody;MGC111141 antibody;Zonulin antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S1 family.

TISSUE SPECIFICITY

Expressed by the liver and secreted in plasma.

SUBCELLULAR LOCATION

Extracellular region, secreted.

FUNCTION

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.