HRP Conjugated HA Tag Recombinant Rabbit Monoclonal Antibody [JM10-56] (ET1703-12)

PROTEIN NAME

HA Tag

SYNONYMS

HA epitope tag antibody;HA1 antibody;HA2 antibody;hemagglutinin antibody;Hemagglutinin HA1 chain antibody;Hemagglutinin HA2 chain antibody

FUNCTION

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human influenza virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106. It has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the protein of interest. The HA tag is not suitable for detection or purification of proteins from apoptotic cells since it is cleaved by Caspase-3 and / or Caspase-7 after its sequence DVPD, causing it to lose its immunoreactivity. Labeling of endogenous proteins with HA-tag using CRISPR was recently accomplished in-vivo in differentiated neurons.