H Cadherin Recombinant Rabbit Monoclonal Antibody [JB14-48] (ET7107-76)

UNIPROT #

P55290

PROTEIN NAME

H Cadherin

SYNONYMS

CAD13_HUMAN antibody;Cadherin-13 antibody;CDH13 antibody;CDHH antibody;H-cadherin antibody;Heart cadherin antibody;P105 antibody;T cad antibody;T Cadherin antibody;T-cad antibody;T-cadherin antibody;Truncated cadherin antibody

TISSUE SPECIFICITY

Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.

DEVELOPMENTAL STAGE

Expressed at higher levels in adult brain than in developing brain.

SUBCELLULAR LOCATION

Cell membrane, Membrane.

FUNCTION

Cadherins comprise a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogen-esis. Cadherins each contain a large extracellular domains characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin), also designated heart-cadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cell lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.