GTPBP4 Recombinant Rabbit Monoclonal Antibody [JE47-47] (ET7109-59)

UNIPROT #

Q9BZE4

PROTEIN NAME

GTPBP4

SYNONYMS

Chronic renal failure gene protein antibody;CRFG antibody;G protein binding protein CRFG antibody;GTP binding protein 4 antibody;GTP-binding protein NGB antibody;Gtpbp4 antibody;NGB antibody;NOG1 antibody;NOG1_HUMAN antibody;Nucleolar GTP binding protein 1 antibody;Nucleolar GTP-binding protein 1 antibody

SEQUENCE SIMILARITIES

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.