Recombinant Rabbit monoclonal primary
GTPBP4 Recombinant Rabbit Monoclonal Antibody [JE47-47] (ET7109-59)
Synthetic peptide within n terminal human gtpbp4.
293T cell, human liver cancer tissue, human thyroid gland tissue, human skin tissue, human breast tissue, thp-1.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Chronic renal failure gene protein antibody; CRFG antibody; G protein binding protein CRFG antibody; GTP binding protein 4 antibody; GTP-binding protein NGB antibody; Gtpbp4 antibody; NGB antibody; NOG1 antibody; NOG1_HUMAN antibody; Nucleolar GTP binding protein 1 antibody; Nucleolar GTP-binding protein 1 antibody
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.