GST3 Mouse Monoclonal Antibody [11D5] (EM1801-18)

UNIPROT #

P09211

PROTEIN NAME

GST3

SYNONYMS

Deafness antibody;Deafness X-linked 7 antibody;DFN7 antibody;FAEES3 antibody;Fatty Acid Ethyl Ester Synthase III antibody;Glutathione S Transferase 3 antibody;Glutathione S Transferase Pi antibody;Glutathione S-transferase P antibody;Glutathione S-transferase pi 1 antibody;GST class-pi antibody;GST3 antibody;GSTP antibody;Gstp1 antibody;GSTP1-1 antibody;GSTP1_HUMAN antibody;PI antibody;X linked 7 antibody

SEQUENCE SIMILARITIES

Belongs to the GST superfamily. Pi family.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Mitochondrion.

FUNCTION

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. In response to oxidative stress, upregulation of the GST family member GSTP1 occurs, consistent with this function. Furthermore, the GSTP1 gene is subject to CpG island hypermethylation, a state that correlates with human prostatic carcinogenesis. GSTP1 gene hypermethylation can be detected in urine, ejaculate and plasma from men with prostate cancer, potentially making GSTP1 a useful biomarker for prostate cancer screening.