GSK3 alpha Rabbit Polyclonal Antibody (R1312-1)

UNIPROT #

P49840

PROTEIN NAME

GSK3 alpha

SYNONYMS

DKFZp686D0638 antibody;Glycogen synthase kinase 3 alpha antibody;Glycogen synthase kinase-3 alpha antibody;GSK 3 alpha antibody;GSK 3A antibody;GSK-3 alpha antibody;Gsk3a antibody;GSK3A_HUMAN antibody;GSK3alpha antibody;Serine/threonine protein kinase GSK3A antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Apical dendrite, Mitochondrion.

FUNCTION

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. GSK3 alpha requires primed phosphorylation of the majority of its substrates. It contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. GSK3 alpha regulates glycogen metabolism in liver, but not in muscle. It may also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, GSK3 alpha regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin.