GSDMC Rabbit Polyclonal Antibody (ER1902-22)
Catalog# ER1902-22
Rabbit Polyclonal to GSDMC
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WB
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IHC-P
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Human
Specifications
Product Type
Rabbit polyclonal primary
Product Name
GSDMC Rabbit Polyclonal Antibody (ER1902-22)
Immunogen
Recombinant protein within human gsdmc aa 1-220 / 508.
Host
Rabbit
Positive Control
Human stomach tissue lysates, human lung tissue, human kidney tissue, A549.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB:1:1,000-1:2,000
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IHC-P:1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 58 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
GSDMC
SYNONYMS
Gasdermin C antibody;Gasdermin-C antibody;GSDMC antibody;GSDMC_HUMAN antibody;Melanoma derived leucine zipper, extra nuclear factor antibody;Melanoma-derived leucine zipper-containing extranuclear factor antibody;MLZE antibody
SEQUENCE SIMILARITIES
Belongs to the gasdermin family.
TISSUE SPECIFICITY
Expressed mainly in trachea and spleen. In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium.
SUBCELLULAR LOCATION
Cell membrane, Cytoplasm, Membrane.
FUNCTION
This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown.
CITATIONS
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Jiang Xueqin,et al
NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation
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WB
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Mouse
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Citation
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