GRK3 Rabbit Polyclonal Antibody (HA500317)

UNIPROT #

P35626

PROTEIN NAME

GRK3

SYNONYMS

ADRBK2 antibody;Adrenergic, beta, receptor kinase 2 antibody;ARBK2_HUMAN antibody;BARK2 antibody;Beta adrenergic receptor kinase 2 antibody;Beta ARK 2 antibody;Beta-adrenergic receptor kinase 2 antibody;Beta-ARK-2 antibody;EC 2.7.11.15 antibody;G protein coupled receptor kinase 3 antibody;G-protein-coupled receptor kinase 3 antibody;GRK3 antibody

SUBCELLULAR LOCATION

cytosol, plasma membrane.

FUNCTION

G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an arrestin protein to the receptor. Arrestin binding to phosphorylated, active receptor prevents receptor stimulation of heterotrimeric G protein transducer proteins, blocking their cellular signaling and resulting in receptor desensitization. Arrestin binding also directs receptors to specific cellular internalization pathways, removing the receptors from the cell surface and also preventing additional activation. Arrestin binding to phosphorylated, active receptor also enables receptor signaling through arrestin partner proteins. Thus the GRK/arrestin system serves as a complex signaling switch for G protein-coupled receptors.