GRIM19 Recombinant Rabbit Monoclonal Antibody [JG82-33] (ET7108-66)

UNIPROT #

Q9P0J0

PROTEIN NAME

GRIM19

SYNONYMS

2700054G14Rik antibody;AU022060 antibody;B16.6 antibody;CDA016 antibody;Cell death regulatory protein antibody;Cell death regulatory protein GRIM-19 antibody;CGI-39 antibody;CGI39 protein antibody;CI-B16.6 antibody;Complex I-B16.6 antibody;FLJ58045 antibody;FLJ59191 antibody;Gene associated with retinoic and IFN-induced mortality 19 protein antibody;Gene associated with retinoic and interferon-induced mortality 19 protein antibody;Gene associated with retinoic interferon induced mortality 19 protein antibody;GRIM-19 antibody;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 antibody;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 antibody;NADH ubiquinone oxidoreductase B16.6 subunit antibody;NADH-ubiquinone oxidoreductase B16.6 subunit antibody;NDUAD_HUMAN antibody;NDUFA13 antibody;RGD1565358 antibody

SEQUENCE SIMILARITIES

Belongs to the complex I NDUFA13 subunit family.

TISSUE SPECIFICITY

Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.

DEVELOPMENTAL STAGE

Expressed in numerous fetal tissues.

SUBCELLULAR LOCATION

Mitochondrion. Nucleus.

FUNCTION

The GRIM family of proteins appear to be novel types of tumor suppressors. Grim19, which stands for gene associated with retinoic-interferon-induced mortality 19 protein, is also designated cell death-regulatory protein Grim-19 or NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 13. The Grim19 protein plays two roles within the cell. As a member of the interferon-beta and retinoic acid-induced pathway of cell death, Grim19 induces apoptosis. As part of the mitochondrial complex I, Grim19 is essential for its assembly and electron transfer activity. It transfers electrons to the respiratory chain from NADH and plays a role in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway. It localizes primarily to the mitochondrion, but may translocate to the nucleus upon IFN/RA treatment. Grim19 may also be useful as a biological marker or target for drug development.