GRB7 Rabbit Polyclonal Antibody (HA500328)

UNIPROT #

Q14451

PROTEIN NAME

GRB7

SYNONYMS

B47 antibody;Epidermal growth factor receptor GRB 7 antibody;Epidermal growth factor receptor GRB-7 antibody;GRB7 adapter protein antibody;GRB7 antibody;GRB7_HUMAN antibody;Growth factor receptor bound protein 7 antibody;Growth factor receptor-bound protein 7 antibody;OTTHUMP00000164349 antibody;OTTHUMP00000164350 antibody;OTTHUMP00000164351 antibody;OTTHUMP00000164352 antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Focal adhesion, Cytoplasmic granule, Cell projection.

FUNCTION

Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7, thought to be involved in migration[citation needed], is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.