Granzyme K Recombinant Rabbit Monoclonal Antibody [PSH18-49] (HA724002)

UNIPROT #

P49863

PROTEIN NAME

Granzyme K

SYNONYMS

Fragmentin 3 antibody;Fragmentin-3 antibody;Fragmentin3 antibody;GRAK_HUMAN antibody;Granzyme 3 antibody;granzyme K (granzyme 3; tryptase II) antibody;granzyme K (serine protease, granzyme 3; tryptase II) antibody;Granzyme K antibody;Granzyme K precursor antibody;Granzyme-3 antibody;Granzyme3 antibody;GranzymeK antibody;GZMK antibody;NK TRYP 2 antibody;NK TRYP2 antibody;NK tryptase 2 antibody;NK-TRYP-2 antibody;NK-tryptase-2 antibody;NKTRYP2 antibody;Serine protease granzyme 3 antibody;TRYP 2 antibody;TRYP2 antibody;Tryptase II antibody;TryptaseII antibody

SUBCELLULAR LOCATION

Secreted, Cytoplasmic granule.

FUNCTION

Granzyme K (GzmK) is a serine protease that sits in the dense-core granules of cytotoxic T lymphocytes and NK cells. While its gene neighbors encode granzymes A–C, GzmK stands out by lacking the N-linked glycosylation motifs that decorate most family members; this minimalist design keeps it stable at the low pH of the granule and allows it to emerge in an immediately active form once perforin has punched entry holes in a target cell. Inside the cytosol, GzmK bypasses the canonical caspase cascade: it clips Bid to tBid, nicks the anti-apoptotic SET complex, and generates single-stranded DNA nicks that push the cell into a swift form of death intermediate between apoptosis and necrosis. In addition, any GzmK that leaks into the extracellular space can process pro-IL-1β and activate PAR-2 on macrophages and endothelial cells, turning a private hit into a broader inflammatory alert.