Granzyme B Rabbit Polyclonal Antibody (IRS032)

UNIPROT #

P10144

PROTEIN NAME

Granzyme B

SYNONYMS

C11 antibody;Cathepsin G like 1 antibody;Cathepsin G-like 1 antibody;CCPI antibody;CGL 1 antibody;CGL1 antibody;CSP B antibody;CSPB antibody;CTLA 1 antibody;CTLA-1 antibody;CTLA1 antibody;CTSGL1 antibody;Cytotoxic serine protease B antibody;Cytotoxic T lymphocyte associated serine esterase 1 antibody;Cytotoxic T lymphocyte proteinase 2 antibody;Cytotoxic T-lymphocyte proteinase 2 antibody;Fragmentin 2 antibody;Fragmentin-2 antibody;GRAB_HUMAN antibody;Granzyme 2 antibody;Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody;Granzyme B antibody;Granzyme-2 antibody;GranzymeB antibody;GRB antibody;Gzmb antibody;Hlp antibody;Human lymphocyte protein antibody;Lymphocyte protease antibody;Protease, serine, B antibody;SECT antibody;T cell serine protease 1 3E antibody;T cell serine protease 1-3E antibody;T-cell serine protease 1-3E antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse . It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death . Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis .