Granzyme A Recombinant Rabbit Monoclonal Antibody [PSH14-39] (HA723633)

UNIPROT #

P12544

PROTEIN NAME

Granzyme A

SYNONYMS

CTL tryptase antibody;CTLA3 antibody;Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody;Cytotoxic T lymphocyte associated serine esterase 3 antibody;Cytotoxic T lymphocyte proteinase 1 antibody;Cytotoxic T-lymphocyte proteinase 1 antibody;Fragmentin 1 antibody;Fragmentin-1 antibody;GRAA_HUMAN antibody;Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody;Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease) antibody;Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody;Granzyme A antibody;Granzyme A precursor antibody;Granzyme-1 antibody;GZMA antibody;H factor antibody;Hanukah factor serine protease antibody;Hanukkah factor antibody;HF antibody;HFSP antibody;TSP1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.