GPX5 Mouse Monoclonal Antibody [5A1] (M1701-8)

UNIPROT #

O75715

PROTEIN NAME

GPX5

SYNONYMS

Arep;arMEP24;EGLP;Epididymal androgen related protein;Epididymal secretory glutathione peroxidase;epididymis secretory sperm binding protein Li 75p;Epididymis specific glutathione peroxidase like protein;Epididymis-specific glutathione peroxidase-like protein;Glutathione peroxidase 5;Glutathione peroxidase 5 (epididymal androgen related protein);Glutathione peroxidase, epididymal;GPx-5;GPX5;GPX5_HUMAN;GSHPx-5;HEL-S-75p;Major androgen regulated protein;OTTHUMP00000017919;OTTHUMP00000214636

SEQUENCE SIMILARITIES

Belongs to the glutathione peroxidase family.

TISSUE SPECIFICITY

Epididymis.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1-8). GPx-1, Gpx-2 and Gpx-3 exist as homotetramers. Gpx-4 has a high tendancy to form high molecular weight oligomers. GPx-1 plays an important role in the antioxidant defense of the vascular wall and neural cells in response to oxidative stress. GPx-2 is the major isoform in the lungs and its basal or inducible expression is dependent on Nrf2. GPx-3 is under regulation by hypoxic stress and the expression and deficiency of GPx-3 is associated with cardiovascular disease and stroke. GPx-5 is selenium-independent; it is bound to the acrosome of sperm, where it may protect sperm from premature acrosome reaction in the epididymis.