GPR56 Recombinant Rabbit Monoclonal Antibody [PSH05-43] (HA722273)

UNIPROT #

Q9Y653

PROTEIN NAME

GPR56

SYNONYMS

7 transmembrane protein with no EGF like N terminal domains 1 antibody;BFPP antibody;DKFZp781L1398 antibody;EGF TM7 like antibody;G protein coupled receptor 56 antibody;G-protein coupled receptor 56 antibody;GPR 56 antibody;Gpr56 antibody;GPR56_HUMAN antibody;Polymicrogyria bilateral frontoparietal antibody;Protein TM7XN1 antibody;TM7LN4 antibody;TM7XN1 antibody;TM7XN1 protein antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

G protein-coupled receptor 56 also known as TM7XN1 is a protein encoded by the ADGRG1 gene. GPR56 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic precursor, muscle, and developing neural cells in the mouse. GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development. More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells.