GPR49/LGR5 alpha/beta Rabbit Polyclonal Antibody (ER10708)

UNIPROT #

Q9Z1P4

PROTEIN NAME

GPR49/LGR5 alpha/beta

SYNONYMS

FEX antibody;G protein coupled receptor 49 antibody;G protein coupled receptor 67 antibody;g protein-coupled receptor fex antibody;G-protein coupled receptor 49 antibody;G-protein coupled receptor 67 antibody;G-protein coupled receptor HG38 antibody;GPR 49 antibody;GPR 67 antibody;GPR49 antibody;GPR67 antibody;GRP 49 antibody;GRP49 antibody;HG 38 antibody;HG38 antibody;Leucine rich repeat containing G protein coupled receptor 5 antibody;Leucine-rich repeat-containing G-protein coupled receptor 5 antibody;LGR 5 antibody;LGR5 antibody;LGR5_HUMAN antibody;MGC117008 antibody;Orphan G protein coupled receptor HG38 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

SUBCELLULAR LOCATION

Cytoplasm, cell membrane, Golgi apparatus.

FUNCTION

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.