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GPR161 Rabbit Polyclonal Antibody (HA500098)

Price: Regular price $315.00

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Catalog# HA500098

Rabbit Polyclonal to GPR161

Tested for

  • WB

  • IHC-P

Reacts with

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

GPR161 Rabbit Polyclonal Antibody (HA500098)

Immunogen

Recombinant protein within mouse gpr161 aa 323-545.

Host

Rabbit

Positive Control

Mouse cerebellum tissue lysate, rat colon tissue lysate, rat uterus tissue, mouse kidney tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071197

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

60 kDa

Isotype

IgG

TARGET

UNIPROT #

B2RPY5

PROTEIN NAME

GPR161

SYNONYMS

G protein coupled receptor 161 antibody;G protein coupled receptor RE2 antibody;RE2 antibody;Gm208;G-protein coupled receptor 161

SUBCELLULAR LOCATION

Cilium membrane, Cell membrane.

FUNCTION

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

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