Lane 1: Mouse brain tissue lysate
Lane 2: Rat brain tissue lysate
Lane 2: PC-3 cell lysate
Recombinant Rabbit monoclonal primary
GOT2 Recombinant Rabbit Monoclonal Antibody [JE54-46] (ET7110-71)
Synthetic peptide within human got2.
Mouse brain tissue lysate, rat brain tissue lysate, PC-3 cell lysate, zebrafish tissue lysates, rat smooth muscle tissue, human liver tissue, human colon carcinoma tissue, mouse kidney tissue, SiHa.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Predicted band size: 48 kDa.
AATM_HUMAN antibody; AL022787 antibody; Aspartate aminotransferase 2 antibody; Aspartate aminotransferase antibody; Aspartate aminotransferase, mitochondrial antibody; Aspartate transaminase 2 antibody; ASPATA antibody; EC 126.96.36.199 antibody; FABP 1 antibody; FABP pm antibody; FABP-1 antibody; FABPpm antibody; Fatty acid binding protein antibody; Fatty acid-binding protein antibody; FLJ40994 antibody; Glutamate oxaloacetate transaminase 2 antibody; Glutamate oxaloacetate transaminase 2, mitochondrial antibody; Glutamate oxaloacetate transaminase, mitochondrial antibody; Glutamic oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) antibody; Got 2 antibody; GOT2 antibody; KAT4 antibody; KATIV antibody; kynurenine aminotransferase 4 antibody; Kynurenine aminotransferase IV antibody; kynurenine--oxoglutarate transaminase 4 antibody; kynurenine--oxoglutarate transaminase IV antibody; mAspAT antibody; MGC102129 antibody; MGC115763 antibody; mitAAT antibody; mitochondrial antibody; Mitochondrial aspartate aminotransferase antibody; OTTMUSP00000017748 antibody; Plasma membrane fatty acid binding protein antibody; Plasma membrane-associated fatty acid-binding protein antibody; Transaminase A antibody
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Cell membrane, mitochondrion matrix.
Aspartate aminotransferase, mitochondrial is an enzyme that in humans is encoded by the GOT2 gene. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. Also, GOT2 is a major participant in the malate-aspartate shuttle, which is a passage from the cytosol to the mitochondria. The two enzymes are homodimeric and show close homology. GOT2 has been seen to have a role in cell proliferation, especially in terms of tumor growth. GOT2 and another enzyme, MDH, are essential for the functioning of the shuttle. GOT2 converts oxaloacetate into aspartate by transamination. This aspartate as well as alpha-ketoglutarate return into the cytosol, which is then converted back to oxaloacetate and glutamate, respectively. Another function of GOT2 is that it is believed to transaminate kynurenine into kynurenic acid (KYNA) in the brain. The KYNA made by the GOT2 is thought to be an important factor in brain pathology.