Recombinant Rabbit monoclonal primary
GOLPH2 Recombinant Rabbit Monoclonal Antibody [JA63-03] (ET1704-64)
SH-SY5Y cell lysate, 293T, A549, Hela, human prostate tissue, mouse small intestine tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
bA379P1.3 antibody; C9orf155 antibody; Chromosome 9 open reading frame 155 antibody; Golgi membrane protein 1 antibody; Golgi membrane protein GP73 antibody; Golgi phosphoprotein 2 antibody; Golgi protein 73 kD antibody; Golgi protein 73kD antibody; GOLM 1 antibody; GOLM1 antibody; GOLM1_HUMAN antibody; GOLPH 2 antibody; GOLPH2 antibody; GP 73 antibody; GP73 antibody; PSEC0257 antibody
Belongs to the GOLM family.
Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.
Glycosylated.; Phosphorylation sites are present in the extracellular medium.
GP73 (also known as Golgi phosphoprotein 2, GOLPH 2 or Golgi membrane protein), is a widely expressed, epithelial-specific, type II transmembrane protein which resides in the Golgi apparatus, where it is responsible for the posttranslational modification of proteins produced in the Rough ER while assisting in the transport of proteins through the Golgi. The human GP73 gene has been mapped within a BAC and localized to chromosome 9q21.33. GP73 levels rise in those who have been diagnosed with acute and chronic liver diseases.