GNB3 Rabbit Polyclonal Antibody (HA500127)
Catalog# HA500127
Rabbit Polyclonal to GNB3
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WB
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IF-Cell
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: HepG2 cell lysate
Lane 2: A549 cell lysate
Lane 3: Mouse kidney tissue lysate
Lane 4: Rat brian tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
GNB3 Rabbit Polyclonal Antibody (HA500127)
Immunogen
Synthetic peptide within human gnb3 aa 100-150.
Host
Rabbit
Positive Control
HepG2 cell lysate, A549 cell lysate, mouse kidney tissue lysate, rat brian tissue lysate, F9, rat kidney tissue, mouse brian tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:1,000-1:5,000
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IF-Cell
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1:50-1:200
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
37 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
GNB3
SYNONYMS
G protein beta 3 subunit antibody;GBB3_HUMAN antibody;GNB3 antibody;GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 antibody;GTP binding regulatory protein beta 3 chain antibody;Guanine nucleotide binding protein (G protein) beta polypeptide 3 antibody;Guanine nucleotide binding protein G antibody;Guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 3 antibody;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 antibody;Hypertension associated protein antibody;IG antibody;SG antibody;Transducin beta chain 3 antibody;Tsubunit beta 3 antibody
SUBCELLULAR LOCATION
Cytosol, Extracellular region or secreted, Plasma Membrane.
FUNCTION
Heterotrimeric guanine nucleotide-binding proteins ( G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
CITATIONS
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He Chanting,et al
The mechanism of miR-665 targeting GNB3 in aluminum-induced neuronal apoptosis
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WB
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Rat
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Citation
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