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PRODUCT CODE: 0804-8

GM-CSF-R-alpha (CD116) Rabbit Polyclonal Antibody (0804-8)

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

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Western blot analysis on F9 cell lysates using anti- GM-CSF-R-alpha polyclonal antibody.
  • Western blot analysis on F9 cell lysates using anti- GM-CSF-R-alpha polyclonal antibody.
Western blot analysis on F9 cell lysates using anti- GM-CSF-R-alpha polyclonal antibody.

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

GM-CSF-R-alpha (CD116) Rabbit Polyclonal Antibody (0804-8)

Immunogen

Synthetic peptide within n-terminal mouse gm-csf-r-alpha (cd116).

Host

Rabbit

Positive Control

F9

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

70/42kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:1000

  • ICC

  • 1:100-1:200

  • FC

  • 1:10-1:100

TARGET

UNIPROT #

Q00941

PROTEIN NAME

GM-CSF-R-alpha (CD116)

SYNONYMS

CD_antigen=CD116 antibody; CD116 antibody; CD116 antigen antibody; CDw116 antibody; Colony stimulating factor 2 receptor alpha chain antibody; Colony stimulating factor 2 receptor alpha low affinity antibody; Colony stimulating factor 2 receptor alpha subunit antibody; CSF 2R antibody; CSF2R antibody; CSF2R_HUMAN antibody; CSF2RA antibody; CSF2RAX antibody; CSF2RAY antibody; CSF2RX antibody; CSF2RY antibody; GM CSF R alpha antibody; GM CSF receptor alpha subunit antibody; GM-CSF-R-alpha antibody; GMCSFR antibody; GMCSFR-alpha antibody; GMR-alpha antibody; Granulocyte macrophage colony stimulating factor receptor alpha chain antibody; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody; SMDP4 antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 5 subfamily.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

The granulocyte macrophage–colony-stimulating factor receptor (GM-CSF-R) is a heterodimer composed of 2 subunits,αand ?, and ligand binding to the high-affinity receptor leads to signalling for the multiple actions of GM-CSF on target cells. The GM-CSF receptors are found on the surface of myeloid precursors, granulocytes, mononuclear phagocyte, and also frequently present on the myeloid malignancies. The GM-CSF-R-alpha transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

CITATIONS

  • Tan, Zhou et al.

    Production of rabbit monoclonal antibodies against mouse embryonic stem cells and identification of pluripotency-associated surface antigens. | Journal of Immunological Methods [2011]