GM-CSF-R-alpha (CD116) Rabbit Polyclonal Antibody (0804-8)

UNIPROT #

Q00941

PROTEIN NAME

GM-CSF-R-alpha (CD116)

SYNONYMS

CD_antigen=CD116 antibody;CD116 antibody;CD116 antigen antibody;CDw116 antibody;Colony stimulating factor 2 receptor alpha chain antibody;Colony stimulating factor 2 receptor alpha low affinity antibody;Colony stimulating factor 2 receptor alpha subunit antibody;CSF 2R antibody;CSF2R antibody;CSF2R_HUMAN antibody;CSF2RA antibody;CSF2RAX antibody;CSF2RAY antibody;CSF2RX antibody;CSF2RY antibody;GM CSF R alpha antibody;GM CSF receptor alpha subunit antibody;GM-CSF-R-alpha antibody;GMCSFR antibody;GMCSFR-alpha antibody;GMR-alpha antibody;Granulocyte macrophage colony stimulating factor receptor alpha chain antibody;Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody;SMDP4 antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 5 subfamily.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

The granulocyte macrophage–colony-stimulating factor receptor (GM-CSF-R) is a heterodimer composed of 2 subunits,αand ?, and ligand binding to the high-affinity receptor leads to signalling for the multiple actions of GM-CSF on target cells. The GM-CSF receptors are found on the surface of myeloid precursors, granulocytes, mononuclear phagocyte, and also frequently present on the myeloid malignancies. The GM-CSF-R-alpha transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.