GM-CSF Mouse Monoclonal Antibody [A6C5] (HA601033)

UNIPROT #

P04141

PROTEIN NAME

GM-CSF

SYNONYMS

Colony stimulating factor 2 (granulocyte-macrophage) antibody;Colony Stimulating Factor 2 antibody;Colony stimulating factor antibody;Colony-stimulating factor antibody;CSF 2 antibody;CSF antibody;CSF2 antibody;CSF2_HUMAN antibody;GM-CSF antibody;GMCSF antibody;Granulocyte Macrophage Colony Stimulating Factor antibody;Granulocyte-macrophage colony-stimulating factor antibody;MGC131935 antibody;MGC138897 antibody;MGI1GM antibody;Molgramostin antibody;Pluripoietin-a antibody;Sargramostim antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils. GM-CSF is found in high levels in joints with rheumatoid arthritis and blocking GM-CSF as a biological target may reduce the inflammation or damage. Some drugs (e.g. otilimab) are being developed to block GM-CSF. In critically ill patients GM-CSF has been trialled as a therapy for the immunosuppression of critical illness, and has shown promise restoring monocyte and neutrophil function, although the impact on patient outcomes is currently unclear and awaits larger studies. GM-CSF stimulates monocytes and macrophages to produce pro-inflammatory cytokines, including CCL17. Elevated GM-CSF has been shown to contribute to inflammation in inflammatory arthritis, osteoarthritis, colitis asthma, obesity, and COVID-19.