Glutathione S Transferase mu Recombinant Rabbit Monoclonal Antibody [JE36-67] (HA721463)

UNIPROT #

P09488

PROTEIN NAME

Glutathione S Transferase mu

SYNONYMS

Glutathione S alkyltransferase antibody;Glutathione S aralkyltransferase antibody;Glutathione S aryltransferase antibody;Glutathione S transferase M1 antibody;Glutathione S transferase mu 1 antibody;Glutathione S transferase mu antibody;Glutathione S-transferase Mu 1 antibody;GST class mu 1 antibody;GST class Mu antibody;GST class-mu 1 antibody;GST HB subunit 4 antibody;GST mu antibody;GST1 antibody;GSTM1 1 antibody;Gstm1 antibody;GSTM1-1 antibody;GSTM1_HUMAN antibody;GSTM1a 1a antibody;GSTM1a-1a antibody;GSTM1b 1b antibody;GSTM1b-1b antibody;GTH4 antibody;GTM1 antibody;H B antibody;HB subunit 4 antibody;MGC26563 antibody;MU 1 antibody;MU antibody;S (hydroxyalkyl)glutathione lyase antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.