Glutathione Peroxidase 2 Recombinant Rabbit Monoclonal Antibody [JE40-73] (HA721485)

UNIPROT #

P18283

PROTEIN NAME

Glutathione Peroxidase 2

SYNONYMS

Gastrointestinal glutathione peroxidase antibody;GI GPx antibody;Glutathione peroxidase 2 (gastrointestinal) antibody;Glutathione peroxidase 2 antibody;Glutathione peroxidase gastrointestinal antibody;Glutathione peroxidase related protein 2 antibody;Glutathione peroxidase-gastrointestinal antibody;Glutathione peroxidase-related protein 2 antibody;GPRP antibody;GPRP-2 antibody;GPx 2 antibody;GPx-2 antibody;GPx-GI antibody;GPX2 antibody;GPX2_HUMAN antibody;GSHPx 2 antibody;GSHPx GI antibody;GSHPx-2 antibody;GSHPx-GI antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol.

FUNCTION

Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene. This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract. The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.