Glucose Transporter GLUT4 Recombinant Rabbit Monoclonal Antibody [PSH10-06] (HA723175)

UNIPROT #

P14142

PROTEIN NAME

Glucose Transporter GLUT4

SYNONYMS

insulin-responsive antibody;Glucose transporter GLUT 4 antibody;Glucose transporter type 4 antibody;Glucose transporter type 4 insulin responsive antibody;GLUT 4 antibody;GLUT-4 antibody;GLUT4 antibody;GTR4_HUMAN antibody;Insulin responsive glucose transporter type 4 antibody;kug antibody;SLC 2A4 antibody;SLC2A4 antibody;solute carrier family 2 (facilitated glucose transporter) member 4 antibody;Solute carrier family 2 member 4 antibody;Solute carrier family 2, facilitated glucose transporter member 4 antibody

SUBCELLULAR LOCATION

Cell membrane, Endomembrane system, Cytoplasm, perinuclear region.

FUNCTION

Glucose transporter type 4 (GLUT4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac). At the cell surface, GLUT4 permits the facilitated diffusion of circulating glucose down its concentration gradient into muscle and fat cells. Once within cells, glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form glucose-6-phosphate, which then enters glycolysis or is polymerized into glycogen. Glucose-6-phosphate cannot diffuse back out of cells, which also serves to maintain the concentration gradient for glucose to passively enter cells.