Glucose 6 Phosphate Dehydrogenase Recombinant Rabbit Monoclonal Antibody [JA31-40] (ET1704-39)

UNIPROT #

P11413

PROTEIN NAME

Glucose 6 Phosphate Dehydrogenase

SYNONYMS

G6PD antibody;G6PD_HUMAN antibody;G6PD1 antibody;G6pdx antibody;Glucose 6 phosphate 1 dehydrogenase antibody;Glucose 6 phosphate dehydrogenase antibody;Glucose 6 phosphate dehydrogenase, G6PD antibody;Glucose-6-phosphate 1-dehydrogenase antibody;MET19 antibody;POS10 antibody;Zwf1p antibody

SEQUENCE SIMILARITIES

Belongs to the glucose-6-phosphate dehydrogenase family.

TISSUE SPECIFICITY

Isoform Long is found in lymphoblasts, granulocytes and sperm.

POST-TRANSLATIONAL MODIFICATION

Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.

SUBCELLULAR LOCATION

Cytoplasm. Cytoplasmic side of plasma membrane. Membrane. Nucleus.

FUNCTION

Glucose-6-phosphate 1-dehydrogenase (G6PD) plays an important role in the pentose phosphate pathway. It is a member of the glucose-6-phosphate dehydrogenase family of proteins. G6PD is a ubiquitous enzyme that produces pentose sugars for nucleic acid synthesis, but is also involved in carbohydrate degradation, as it is one of the main producers of NADPH reducing power. G6PD has NADP as a co-factor and structural element. It can be found as a homodimer or homotetramer, and is primarily detected in lymphoblasts, granulocytes and sperm. Defects in G6PD can cause chronic non-spherocytic hemolytic anemia (CNSHA), especially in areas in which malaria is an epidemic. Individuals with a high level of G6PD-deficiency are at higher risk of acute hemolytic attacks.