GKAP Rabbit Polyclonal Antibody (HA500018)

UNIPROT #

O14490

PROTEIN NAME

GKAP

SYNONYMS

4933422O14Rik antibody;9630002F18 antibody;AI845682 antibody;AI848168 antibody;BB075781 antibody;D17Bwg0511e antibody;DAP 1 ALPHA antibody;DAP 1 antibody;DAP 1 BETA antibody;DAP-1 antibody;DAP-1-ALPHA antibody;DAP-1-BETA antibody;DAP1 antibody;Discs large (Drosophila) homolog associated protein 1 antibody;Discs large homolog associated protein 1 antibody;Disks large associated protein 1 antibody;Disks large associated protein 1, alpha isoform, included antibody;Disks large associated protein 1, beta isoform, included antibody;Disks large-associated protein 1 antibody;DLGAP 1 antibody;Dlgap1 antibody;DLGP1_HUMAN antibody;GKAP antibody;GKAP/SAPAP antibody;GKPA/SAPAP antibody;Guanylate kinase associated protein antibody;Guanylate kinase-associated protein antibody;hGKAP antibody;KIAA4162 antibody;MGC88156 antibody;mKIAA4162 antibody;PSD 95/SAP90 binding protein 1 antibody;PSD-95/SAP90-binding protein 1 antibody;SAP90/PSD 95 associated protein 1 antibody;SAP90/PSD-95-associated protein 1 antibody;SAPAP 1 antibody;SAPAP1 antibody

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Membrane, Synapse.

FUNCTION

The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic density, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic density also resets the synapse after each synaptic firing. It is composed of numerous proteins including a family of Discs large associated protein 1, 2, 3 and 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic density. They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors, to signalling proteins and to components of the cytoskeleton. With the central localisation in the postsynapse, the DLGAP family seems to play a vital role in synaptic scaling by regulating the turnover of both ionotropic and metabotropic glutamate receptors in response to synaptic activity. DLGAP family has been directly linked to a variety of psychological and neurological disorders. In this review we focus on the direct and indirect role of DLGAP family on schizophrenia as well as other brain diseases.