GIRK2 Recombinant Rabbit Monoclonal Antibody [PSH05-91] (HA722478)

UNIPROT #

P48051

PROTEIN NAME

GIRK2

SYNONYMS

inwardly rectifying subfamily J member 6 antibody;BIR1 antibody;G protein activated inward rectifier potassium channel 2 antibody;G protein-activated inward rectifier potassium channel 2 antibody;GIRK-2 antibody;GIRK2 antibody;hiGIRK2 antibody;Inward rectifier K(+) channel Kir3.2 antibody;Inward rectifier potassium channel KIR3.2 antibody;KATP-2 antibody;KATP2 antibody;KCNJ6 antibody;KCNJ6_HUMAN antibody;Kcnj7 antibody;KIR3.2 antibody;KPLBS antibody;Potassium channel antibody;Potassium channel inwardly rectifying subfamily J member 6 antibody;Potassium inwardly rectifying channel subfamily J member 6 antibody;Potassium voltage gated channel subfamily J member 6 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability.