GGA1 Rabbit Polyclonal Antibody (HA500534)

UNIPROT #

Q9UJY5

PROTEIN NAME

GGA1

SYNONYMS

4930406E12Rik antibody;ADP ribosylation factor binding protein 1 antibody;ADP ribosylation factor binding protein GGA1 antibody;ADP-ribosylation factor-binding protein GGA1 antibody;ARF binding protein 1 antibody;ARF-binding protein 1 antibody;Gamma adaptin related protein 1 antibody;gamma ear-containing antibody;Gamma-adaptin-related protein 1 antibody;GGA 1 antibody;GGA1 antibody;GGA1 protein antibody;GGA1_HUMAN antibody;Golgi associated gamma adaptin ear containing ARF antibody;Golgi associated gamma adaptin ear containing ARF binding protein 1 antibody;Golgi localized gamma ear containing ARF binding protein 1 antibody;Golgi-localized antibody;OTTHUMP00000028975 antibody;OTTHUMP00000042200 antibody

SUBCELLULAR LOCATION

Golgi apparatus, trans-Golgi network membrane, Endosome membrane, Early endosome membrane.

FUNCTION

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene. This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. GGA1 has been shown to interact with Sortilin 1, BACE2, RABEP1 and ARF3.