Rabbit polyclonal primary
Geminin Rabbit Polyclonal Antibody (R1204-2)
Hela cell lysates, NCCIT, F9, HepG2.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified.
DNA replication inhibitor antibody; Gem antibody; GEMI_HUMAN antibody; Geminin antibody; Geminin DNA replication inhibitor antibody; GMNN antibody; OTTHUMP00000039393 antibody; RP3 369A17.3 antibody
Belongs to the geminin family.
Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition.
Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.
Geminin is a nuclear protein that is present in most eukaryotics and highly conserved across species. Numerous functions have been elucidated for Geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. During S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNAi results in re-replication of portions of the genome, which leads to aneuploidy.