Gemin 2 Rabbit Polyclonal Antibody (HA500045)

UNIPROT #

O14893

PROTEIN NAME

Gemin 2

SYNONYMS

Component of gems 2 antibody;Gem (nuclear organelle) associated protein 2 antibody;Gem associated protein 2 antibody;GEMI2_HUMAN antibody;Gemin-2 antibody;gemin2 antibody;SIP 1 antibody;SIP-1 antibody;SIP1 antibody;SIP1 delta antibody;SIP1-delta antibody;SMN interacting protein 1 antibody;SMN interacting protein 1 delta antibody;SMN-interacting protein 1 antibody;Survival interacting protein 1 antibody;Survival of motor neuron protein interacting protein 1 antibody;Survival of motor neuron protein-interacting protein 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.