GCSF Receptor Rabbit Polyclonal Antibody (HA500282)

UNIPROT #

Q99062

PROTEIN NAME

GCSF Receptor

SYNONYMS

CD 114 antibody;CD114 antibody;CD114 antigen antibody;Colony stimulating factor 3 receptor (granulocyte) antibody;Colony stimulating factor 3 receptor antibody;CSF 3R antibody;CSF3R antibody;CSF3R_HUMAN antibody;Csfgr antibody;G CSF R antibody;G-CSF receptor antibody;G-CSF-R antibody;GCSFR antibody;Granulocyte colony stimulating factor receptor antibody;Granulocyte colony-stimulating factor receptor antibody;OTTHUMP00000009703 antibody;OTTHUMP00000009704 antibody;OTTHUMP00000009705 antibody

SUBCELLULAR LOCATION

Secreted, Cell membrane.

FUNCTION

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Mutations in CSF3R acquired in multipotent hematopoietic progenitor cells and resulting in truncated hyper-responsive forms of the receptor, have been identified in most cases of severe congenital neutropenia (SCN). Patients carrying these mutations are at risk for developing myelodysplastic syndromes and/or acute myeloid leukemia. Constitutive mutations leading to hyporesponsive forms of the receptor are responsible for the refractoriness to CSF3 treatment observed in some SCN patients.