GCDFP 15 Recombinant Rabbit Monoclonal Antibody [JE48-53] (ET7109-80)

UNIPROT #

P12273

PROTEIN NAME

GCDFP 15

SYNONYMS

BRST-2 antibody;BRST2 antibody;GCDFP-15 antibody;GCDGP15 antibody;gp17 antibody;GPIP4 antibody;Gross cystic disease fluid protein 15 antibody;PIP antibody;PIP_HUMAN antibody;Prolactin induced protein antibody;Prolactin inducible protein precursor antibody;Prolactin-induced protein antibody;Prolactin-inducible protein antibody;SABP antibody;Secretory actin binding protein antibody;Secretory actin-binding protein antibody

SEQUENCE SIMILARITIES

Belongs to the PIP family.

TISSUE SPECIFICITY

Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Prolactin-inducible protein also known as gross cystic disease fluid protein 15 (GCDFP-15), extra-parotid glycoprotein (EP-GP), gp17 seminal actin-binding protein (SABP) or BRST2 is a protein that in humans is encoded by the PIP gene. It is upregulated by prolactin and androgens and downregulated by estrogen. The protein has a physiological function in regulation of water transport mainly in apocrine glands in the axilla, vulva, eyelid and ear canal, serous cells of the submandibular salivary gland, serous cells of the submucosal glands of the bronchi, and accessory lacrimal glands as well as cutaneous eccrine glands. It is also found in amniotic fluid and seminal fluid. PIP has the ability to bind immunoglobulin G (IgG), IgG-Fc, CD4-T cell receptor suggesting a wide range of immunological functions. PIP also binds to AZGP1. PIP exerts aspartyl proteinase activity able to cleave fibronectin. PIP can bind different species of bacteria showing highest affinity to streptococci thus playing a role in non-immune defense of the body against pathogenic bacterial strains. Mitogenic effect of PIP was observed on both normal and malignant breast epithelial cells.